Επιλογή Σελίδας

SANITURA (ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΣΤΟΧΩΝ ΚΑΙ ΑΝΑΠΤΥΞΗ ΚΑΙΝΟΤΟΜΩΝ ΠΡΟΣΕΓΓΙΣΕΩΝ ΓΙΑ ΕΦΑΡΜΟΓΕΣ ΣΤΗΝ ΥΓΕΙΑ ΚΑΙ ΤΟ ΠΕΡΙΒΑΛΛΟΝ)

Το έργο SANITURA (MIS 5002514) εντάσσεται στη Δράση Στρατηγικής Ανάπτυξης Ερευνητικών και Τεχνολογικών Φορέων και χρηματοδοτείται από το Επιχειρησιακό Πρόγραμμα «Ανταγωνιστικότητα, Επιχειρηματικότητα και Καινοτομία» στο πλαίσιο του ΕΣΠΑ 2014-2020, με τη συγχρηματοδότηση της Ελλάδας και της Ευρωπαϊκής Ένωσης (Ευρωπαϊκό Ταμείο Περιφερειακής Ανάπτυξης). Αντικείμενό του είναι η ενίσχυση των ερευνητικών δραστηριοτήτων του ΙΒΕ στο πλαίσιο της ανάπτυξης και της αριστείας και οι οποίες εντάσσονται στις Εθνικές Αναπτυξιακές Δραστηριότητες, όπως η κατανόηση μηχανισμών ασθενειών/προσδιορισμό βιοδεικτών και νέων φαρμακευτικών στόχων, η ανάπτυξη προκλινικών και ζωϊκών μοντέλων ασθενειών, η εξεύρεση βιοδραστικών μορίων και φυτικών προϊόντων για φαρμακευτικές και καλλυντικές εφαρμογές και η ανάπτυξη περιβαλλοντικής τεχνολογίας για τη μείωση του περιβαλλοντικού αποτυπώματος στον αγροδιατροφικό τομέα. Επίσης, στο πλαίσιο του Υποέργου εκπαιδεύεται σημαντικός αριθμός νέων επιστημόνων, βοηθώντας στη μείωση της διαρροής νέων επιστημόνων στο εξωτερικό, ενώ τα αποτελέσματα των ερευνητικών δραστηριοτήτων ανακοινώνονται τόσο στην επιστημονική κοινότητα όσο και στο ευρύ κοινό.

ΔΗΜΟΣΙΕΥΣΕΙΣ

Οι ακόλουθες δημοσιεύσεις έχουν προκύψει με την υποστήριξη του έργου SANITURA:

  1. Valanti E.K., Chroni A. and Sanoudou D. The future of apolipoprotein E mimetic peptides in the prevention of cardiovascular disease. Opin. Lipidol. 30, 326-341 (2019).
  2. Dafnis I., Raftopoulou C., Mountaki C., Megalou E. Zannis V. I. and Chroni A. ApoE isoforms and carboxyl-terminal truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity. Biochem J. 475, 1839-1859 (2018).
  3. Dafnis I., Argyri L., and Chroni A. Amyloid-peptide β 42 enhances the oligomerization and neurotoxicity of apoE4: the C-terminal residues Leu279, Lys282 and Gln284 modulate the structural and functional properties of apoE4. Neuroscience 394, 144-155 (2018). (Εικόνα του άρθρου επιλέχθηκε για το εξώφυλλο του τεύχους)
  4. Delimitsou A., F. Fostira, D. Kalfakakou, P. Apostolou, I. Konstantopoulou, C. Kroupis, A.G. Papavassiliou, Z. Kleibl, E. Stratikos, G.E. Voutsinas+, D. Yannoukakos+ (2019) Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system, Human Mutation 40(5):631-648, +equal authorship. (IF: 5.359)
  5. Lesgidou, N., Eliopoulos, E., Goulielmos, G.N. and Vlassi, M. (2018) Insights on the alteration of functionality of a tyrosine kinase 2 variant: A molecular dynamics study. Bioinformatics, 34 (17), i781–i786 ( https://doi.org/10.1093/bioinformatics/bty556 )
  6. Vlassi, M., Kyritsis, K. A., Vizirianakis, I. S., Giannakouros, T., Aivaliotis, M., Nikolakaki, E. (2019). Data on the expression of SRPK1a in mammals. Data in Brief, 25 92019)  104210: 1-6 ( https://doi.org/10.1016/j.dib.2019.104210)
  7. Apostolou-Karampelis, D.Polychronopoulos&Y.Almirantis. Introduction of ‘Generalized Genomic Signatures’ for the quantification of neighbor preferences leads to taxonomy- and functionality-based distinction among sequences. Scientific Reports (2019). DOI:10.1038/s41598-018-38157-3
  8. Feng, M., Fei, S., Xia, J., Labropoulou, V., Swevers, L., and Sun, J. (2020). Antimicrobial peptides as potential antiviral factors in insect antiviral immune response. Front. Immunol. 11, 2020.
  9. Biratsi et al., A highly conserved mechanism for the detoxification and assimilation of the toxic phytoproduct L‑azetidine‑2‑carboxylic acid in Aspergillus nidulans. Scientific Reports 2021, https://doi.org/10.1038/s41598-021-86622-3
  10. Vayenos D., RomanosEm. G., Papageorgiou G. C., Stamatakis K. (2020) The freshwater cyanobacterium Synechococcus sp. PCC7942 under salt stress:  A cell factory for sucrose and hydrogen production. Photosynth. 146(1-3): 235–245
  11. Sagnou, M., Mavroidi, B., Shegani, A.,  Paravatou-Petsotas, M.,  Raptopoulou, C.,  Psycharis, V.,  Pirmettis,  I., Papadopoulos, M.,  Maria Pelecanou. (2019). Remarkable brain penetration of cyclopentadienyl M(CO)3+ (M = 99mTc, Re) derivatives of benzothiazole and benzimidazole paves the way for their application as diagnostic, with Single Photon Emission Computed Tomography (SPECT), and therapeutic agents for Alzheimer’s disease.  J. Med. Chem. 62, 2638-2650
  12. Kazantzis K.T., Koutsonikoli K., Mavroidi B., Zachariadis M., Alexiou P., Pelecanou M., Politopoulos K., Alexandratou E., Sagnou M. (2020). Curcumin derivatives as photosensitizers in Photodynamic Therapy: photophysical properties and in vitro studies with prostate cancer cells. Photochem. Photobiol. Sci. 19, 193–206
  13. Matiadis, D., Mavroidi, B., Panagiotopoulou, A., Methenitis, C., Pelecanou, M., Sagnou, M. (2020). (E)-(1-(4-Ethoxycarbonylphenyl)-5-(3,4-dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-2-pyrazoline: Synthesis, Characterization, DNA-Interaction, and Evaluation of Activity Against Drug-Resistant Cell Lines. Molbank, M1114
  14. Sagnou, M., Mavroidi, B., Kaminari, A., Boukos, N., Pelecanou, M. (2020). Novel isatinthiosemicarbazone derivatives as potent inhibitors of β-amyloid peptide (Αβ) aggregation and toxicity.    ACS Chem. Neurosci. 11, 2266-2276
  15. Mourtas, S., Mavroidi, B., Marazioti, A., Kannavou, M., Sagnou, M., Pelecanou, M., Antimisiaris, S.G. (2020). Liposomes Decorated with 2‑(4′-Aminophenyl)benzothiazole Effectively Inhibit Aβ1−42 Fibril Formation and Exhibit in Vitro Brain- Targeting Potential. Biomacromolecules, 21, 4685-4698
  16. Kaminari A, Tsilibary EC, Tzinia A. A New Perspective in Utilizing MMP-9 as a Therapeutic Target for Alzheimer’s Disease and Type 2 Diabetes Mellitus. J Alzheimers Dis. 2018;64(1):1-16. doi: 10.3233/JAD-180035.
  17. Liu, J., Swevers, L., Kolliopoulou, A., and Smagghe, G. (2019). Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction With the RNAi Mechanism. Front. Physiol. 10, 890.
  18. Kolliopoulou, A., Santos, D., Taning, C.N.T., Wynant, N., VandenBroeck, J., Smagghe, G., and Swevers, L. (2019). PIWI pathway against viruses in insects. Wiley Interdiscip Rev RNA. 2019, e1555.
  19. Swevers, L., Liu, J., and Smagghe, G. (2018). Defense mechanisms against viral infection in Drosophila: RNAi and non-RNAi. Viruses  10, 230.
  20. Zhao, Y., Sun, J., Labropoulou, V., and Swevers, L. (2018). Beyond baculoviruses: additional biotechnological platforms based on insect RNA viruses. Adv. Insect Physiol. 55, 123-162.
  21. Wang, L., Cappelle, K., Santos, D., VandenBroeck, J., Smagghe, G., and Swevers, L. (2019). Short-term persistence precedes pathogenic infection: Infection kinetics of cricket paralysis virus in silkworm-derived Bm5 cells. J, Insect Physiol. 115, 1-11.
  22. Zhao, Y., Kolliopoulou, A., Ren, F., Lu, Q., Labropoulou, V., Swevers, L., and Sun, J. (2019). Transcriptional response of immune-related genes after endogenous expression of VP1 and exogenous exposure to VP1-based VLPs and CPV virions in lepidopteran cell lines. Mol. Genet. Genomics 294, 887-899.
  23. Swevers, L., Feng, M., Ren, F., and Sun, J. (2020). Antiviral defense against Cypovirus 1 (Reoviridae) infection in the silkworm, Bombyxmori. Arch. Insect Biochem. Physiol. 103, e21616.
  24. Kolliopoulou, A., Kontogiannatos, D., and Swevers, L.(2020). The Use of Engineered Plant Viruses in a Trans-Kingdom Silencing Strategy Against Their Insect Vectors. Front. Plant Sci. 11, 917.
  25. Chrysargyris et al. (2021) Organic Cultivation and Deficit Irrigation Practices to Improve Chemical and Biological Activity of Menthaspicata Plants. Agronomy 11, 599. doi: 10.3390/agronomy11030599
  26. Galeou A. and Prombona A. (2020) Daily rhythmic leaf movements and expression of circadian clock genes are differentially synchronized by light in Phaseolus vulgaris (Plant Gene 23,100245).
  27. Gournas A. Athanasopoulos and V. Sophianopoulou 2018. On the Evolution of Specificity in Members of the Yeast Amino Acid Transporter Family as Parts of Specific Metabolic Pathways Int. J. Mol. Sci.19(5), 1398. https://doi.org/10.3390/ijms19051398
  28. Mavrogonatou E., Kouroumalis A., Papadopoulou A., Pratsinis H., Kletsas D. (2021)Cell-based therapies for the regeneration of the intervertebral disc: promises and challenges.ActaOrthopaedica Et Traumatologica Hellenica, 72 (1): 21-29
  29. Mavrogonatou et al. (2019) The role of senescence in cancer development. Semin. Cancer Biol. 62: 182-191 (DOI: 10.1016/j.semcancer.2019.06.018)
  30. Mavrogonatou et al. (2021) Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts. Cancers 13: 1987. doi: 10.3390/cancers13081987
  31. Papadopoulou et al. (2019) Effect of hyperglycaemic conditions on the response of human periodontal ligament fibroblasts to mechanical stretching. Eur.J.Orthod. 2019, 41: 583-590, doi: 10.1093/ejo/cjz051
  32. Papadopoulou et al. (2020) Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts. Biogerontology 2020, 21: 695-708, doi: 10.1007/s10522-020-09886-8.
  33. Papadopoulou et al. (2020) Short- and long-term treatment with TNF-α inhibits the induction of osteoblastic differentiation in cyclic tensile-stretched periodontal ligament fibroblasts. Eur.J.Orthod. 2020 42: 396-406, doi: 10.1093/ejo/cjaa042
  34. Taning et al. (2018) Engineered Flock House Virus for Targeted Gene Suppression Through RNAi in Fruit Flies (Drosophila melanogaster) in Vitro and in Vivo. Front. Physiol. 9:805
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